n. pl. quar·tos
1. The page size obtained by folding a whole sheet into four leaves.
2. A book composed of pages of this size.
[Short for Middle English (in) quarto, (in) the fourth part (of a sheet), from Medieval Latin (in) quārtō, from Latin, ablative of quārtus, fourth; see kwetwer- in the Appendix of Indo-European roots.]
The American Heritage® Dictionary of the English Language, Fifth Edition copyright ©2018 by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
The American Heritage Dictionary Blog
Check out our blog, updated regularly, for new words and revised definitions, interesting images from the 5th edition, discussions of usage, and more.