n. pl. sis·sies
1. A person regarded as timid or cowardly.
2. Offensive A boy or man regarded as effeminate.
3. Informal Sister.
[ Diminutive of SIS.]
sissi·fied′ (-fīd′) adj.
sissi·ness, sissy·ness n.
The American Heritage® Dictionary of the English Language, Fifth Edition copyright ©2020 by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Indo-European & Semitic Roots Appendices
Thousands of entries in the dictionary include etymologies that trace their origins back to reconstructed proto-languages. You can obtain more information about these forms in our online appendices:
The Indo-European appendix covers nearly half of the Indo-European roots that have left their mark on English words. A more complete treatment of Indo-European roots and the English words derived from them is available in our Dictionary of Indo-European Roots.